KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of α-melanocyte-stimulating hormone (α-MSH) that retains potent anti-inflammatory properties while lacking the pigmentary effects of the full-length hormone. This minimalist peptide, consisting of only three amino acids, demonstrates remarkable efficacy in modulating inflammatory responses through multiple pathways, with particular activity in gastrointestinal and cutaneous inflammation models. KPV represents an excellent research tool for investigating localized anti-inflammatory mechanisms, mucosal immunity, and peptide-based therapeutic strategies for inflammatory conditions.